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Is bactrim good for bv. 1 g. 3 days, s. 4 per day and piperazine 50-150mg. b. Biflavin, folic acid and BHA - 50-140 mg 2 times a day for bv. 4 to 8 weeks and piperazine 50-50 mg per morning in the for bv. 2 1 to 6 weeks for bv 7 to 15 weeks with or without piperazine. c. Cushing's syndrome - low dose propranolol 10mg once a day for bv. 4 to 10 weeks and pegestrol acetate 5mg 3 times a day for bv. 4 to 8 weeks with piperazine. d. Hypercalcemia - piperazine 50-100mg for bv. 4 to 8 weeks. e. Kidney failure - BPH piperazine 50-150 mg 3 times a day with or without piperazine for bv. 4 to 10 weeks. F. Drug Abuse. N. S. Bhasin et al, Indian College of Pharmaceutical Chemists, Madras, and Rajiv Bhasin, Indian Medical Association, New Delhi, have carried out extensive experimental studies in laboratory animals to determine the usefulness of pisidine in management narcotics addiction. It has been found that pismidines can be given by administration at the dose and in duration of administration prescribed by the Indian Institute for Health Services; they may Zopiclone in us also be given by subcutaneous injection. When a high dose of pisidine is administered, it has been found that the dose must be reduced by at least 30% and sometimes by 75% depending on the time-course of administration, its total amount per dose and the condition severity of addict. After 30 days administration of pisidine to rats, the animals were given oral administrations of morphine, cocaine, alcohol and opium for two consecutive 24-hr periods. The average dose per subject was 1.1 mg/kg, with the highest and lowest individual amounts being 2.7 and 1.4 mg/kg, respectively. The rats showed marked withdrawal effects within 48 hr of withdrawal from the opioids but after 24 to 48 hrs the withdrawal symptoms disappeared. In addition, the rats showed mild and no serious signs of toxicity. These findings indicate that pisidine would be useful in the management of drug addiction. Further, the administration of pisidine to rats with cocaine dependence at lower doses than those usually used in humans, showed good response and no relapse when used up to an average dose of 1.7 mg/kg; but after 24 to 48 hrs, it showed signs of serious toxicity. Further investigations using doses as low 1.8 mg/kg showed that the rats did not show any signs of toxicity when given up to an average dose of 1.4 mg/kg for a period of 10 week, but after 48 to 72 hrs they displayed withdrawal signs. It was found that an average pisidine Zopiclone 40mg $173.85 - $0.97 Per pill dose of 1 to 2 mg/kg was of sufficient potency to produce symptoms of withdrawals and withdrawal-like reactions at the doses of 1 and 2 mg/kg administered by subcutaneous injection for chronic morphine abuse. Since the withdrawal symptoms of morphine abuse are related to the level of morphine required to induce them at any point of time, subcutaneous administration pisidine might reduce these symptoms. A very significant advantage of pisidine as an abuse medication is that no withdrawal effects are experienced. This property makes pisidine ideal for the treatment of opiate addict and is a very important advantage over other such compounds with high abuse potential. In spite of the fact that most experimental studies have indicated efficacy, more detailed evaluation of pisidine for abuse potential is needed. The pharmacotherapeutic profile of pisidine in animals and humans has been evaluated. It clearly proves to be a very potent analgesic. The activity is largely dependent on the duration and frequency of drug treatment the number routes of administration, but it is very low for pisidine in the presence of same substance in water. When it is administered orally, there a marked increase in the locomotor activity and, more particularly, the body temperature. There is a tendency for the blood viscosity to decrease during and after the administration of pisidine. acute toxicity profile is fairly similar to other potent pain killers. There is no evidence of any severe toxicity in experimental and human clinical studies. In studies, pisidine has shown to be a more effective than morphine in the treatment of addiction.