1.
a. Consider the following types of substitution mutations. Make a table describing the DNA mutation, the effects on the protein and the possible effects on the cell:
transition, transversion, missense, nonsense, neutral, silent and frameshift
b. Consider a protein that has the following sequence of amino acid. This is the wild type protein sequence.
Met – Thr – Cys – His – Ser – Ser …
Mutations of the DNA have led to the following protein sequences. In each case, provide an explanation of a mutation or mutations that are most likely to have could have occurred. Discuss how these mutations will effect the cell.
a. Met – Thr – Ser – His – Ser – Ser …
b. Met – Thr
c. Met – Thr – Leu– Ser – Phe – Phe ……
c. Codons for the same amino acid tend to differ only by the third base position. Why?
